Francine M. Benes Papers Open for Research

By , July 18, 2017

The Center for the History of Medicine is The Center for the History of Medicine is pleased to announce the opening of the Francine M. Benes papers, 1979-2014 (inclusive), 1985-2005 (bulk) to research.

Born in Queens, New York, on May 8, 1946, Francine Benes received her bachelor’s degree from St. John’s University in New York in 1967. In 1972, she completed a PhD in Cell Biology at Yale School of Medicine. Between 1972 and 1975, she received post-doctoral training at the City of Hope National Medical Center in California where she used single cell neurochemistry to study GABA neurons. In 1975, Dr. Benes began medical school at Yale and after receiving her M.D. in 1978, she completed a psychiatric residency at McLean Hospital and Harvard Medical School.

Benes’ research focuses on exploring the post-mortem brains of patients who had a clinical diagnosis of schizophrenia or bipolar disorder, with special focus on determining the role of GABA cells in the pathophysiology of psychotic disorders. Her later research employs microarray-based gene expression profiling (GEP) to explore the genetic causation for GABA cell dysfunction and to determine how molecular mechanisms differ in schizophrenia and bipolar disorder.

The collection reflects Benes’ neuroscientific research focusing on the physical and biochemical changes in brain tissue in bipolar depression and dementia. Records include correspondence, drafts and manuscripts for articles and book chapters, grant proposals, budgets, and reports as well as records reflecting Benes’ professional activities at conferences and professional organizations including as a committee member, panel commentator, or speaker.

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